Impact of baseline HIV-1 RNA levels on initial highly active antiretroviral therapy outcome: a meta-analysis of 12,370 patients in 21 clinical trials*

Author:

Stephan C1,Hill A2,Sawyer W2,van Delft Y3,Moecklinghoff C4

Affiliation:

1. Johann Wolfgang Goethe University Hospital; Frankfurt; Germany

2. MetaVirology Ltd; London; UK

3. Janssen; Tilburg; The Netherlands

4. Janssen; Neuss; Germany

Publisher

Wiley

Subject

Pharmacology (medical),Infectious Diseases,Health Policy

Reference44 articles.

1. Ribaudo H Smith K Robbins G et al Race Differences in the efficacy of initial ART on HIV infection in randomized trials undertaken by ACTG 18 th Conference on Retroviruses and Opportunistic Infections 2011

2. Molina J Diaz-Menendez M Plana M Zamora J Lopez-Velez R Moreno S Very Late initiation of HAART impairs treatment response at 48 and 96 weeks: results from a meta-analysis of randomized trials 13 th European AIDS Conference 2012

3. Why are baseline HIV RNA levels 100,000 copies/mL or greater associated with mortality after the initiation of antiretroviral therapy?;Wood;J Acquir Immune Defic Syndr,2005

4. Baseline HIV-1 RNA level and CD4 cell count predict time to loss of virological response to nelfinavir, but not lopinavir/ritonavir, in antiretroviral therapy-naïve patients;King;J Infect Dis,2004

5. Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): a phase 3, randomized, non-inferiority trial;Cohen;Lancet,2011

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