Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies

Author:

Ligneau Xavier1ORCID,Shah Rashmi R2ORCID,Berrebi-Bertrand Isabelle1,Mirams Gary R3ORCID,Robert Philippe1,Landais Laurent1,Maison-Blanche Pierre4,Faivre Jean-François5,Lecomte Jeanne-Marie1,Schwartz Jean-Charles1

Affiliation:

1. Bioprojet-Biotech; Saint-Grégoire France

2. Pharmaceutical Consultant; Gerrards Cross UK

3. Centre for Mathematical Medicine and Biology, School of Mathematical Sciences; University of Nottingham; Nottingham UK

4. Hôpital Bichat; Paris France

5. Laboratoire Signalisation et Transports Ioniques Membranaires; Université de Poitiers-CNRS; Poitiers France

Funder

Royal Society

Wellcome Trust

Publisher

Wiley

Subject

Pharmacology

Reference54 articles.

1. The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors;Alexander;Br J Pharmacol,2015a

2. The Concise Guide to PHARMACOLOGY 2015/16: Voltage-gated ion channels;Alexander;Br J Pharmacol,2015b

3. The role of late INa in development of cardiac arrhythmias;Antzelevitch;Handb Exp Pharmacol,2014

4. Mexiletine prevents recurrent torsades de pointes in acquired long QT syndrome refractory to conventional measures;Badri;J Am Coll Cardiol EP,2015

5. Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluation drug-induced arrhythmias;Blinova;Toxicol Sci,2017

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