Plasma concentration-dependent suppression of endogenous hydrocortisone in the horse after intramuscular administration of dexamethasone-21-isonicotinate

Author:

Ekstrand C.1,Bondesson U.23,Gabrielsson J.1,Hedeland M.23,Kallings P.45,Olsén L.1,Ingvast-Larsson C.1

Affiliation:

1. Division of Pharmacology and Toxicology; Department of Biomedical Sciences and Veterinary Public Health; Swedish University of Agricultural Sciences; Uppsala Sweden

2. Department of Chemistry, Environment and Feed Hygiene; National Veterinary Institute; Uppsala Sweden

3. Division of Analytical Pharmaceutical Chemistry; Department of Medicinal Chemistry; Uppsala University; Uppsala Sweden

4. Swedish-Norwegian Foundation for Equine Research; Stockholm Sweden

5. Swedish Trotting Association; Stockholm Sweden

Funder

Nordic Equine Medication and Anti-doping Committee

Swedish-Norwegian Foundation for Equine Research

Publisher

Wiley

Subject

General Veterinary,Pharmacology

Reference30 articles.

1. Pharmacokinetics and pharmacodynamics of dexamethasone after intravenous administration in camels: effect of dose;Al Katheeri;Veterinary Research Communications,2004

2. British Horseracing Authority 2014 http://www.britishhorseracing.com/wp-content/uploads/2014/03/Definition-of-a-Prohibited-Substance.pdf

3. The pharmacokinetics of dexamethasone in the thoroughbred racehorse;Cunningham;Journal of Veterinary Pharmacology and Therapeutics,1996

4. Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers;Danhof;Pharmaceutical Research,2005

5. Comparison of 4 basic models of indirect pharmacodynamic responses;Dayneka;Journal of Pharmacokinetics and Biopharmaceutics,1993

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