Affiliation:
1. Emergency Department The Second Affiliated Hospital of Dalian Medical University Dalian Liaoning Province China
2. Department of General Surgery The Second Affiliated Hospital of Dalian Medical University Dalian Liaoning Province China
3. Research and Teaching Department of Comparative Medicine Dalian Medical University Dalian Liaoning Province China
Abstract
Pyroptosis is an inflammasome‐dependent form of programmed cell death that is mediated by caspases‐1, ‐4, ‐5, and ‐11, and the gasdermin protein family. It is characterized by the rupture of cell membrane and the subsequent release of cell contents and interleukins, leading to inflammatory reaction and activation of the immune system. Recent studies have suggested that pyroptosis plays a role in the development of gastrointestinal tumors, impeding tumor generation and progression as well as providing a favorable microenvironment for tumor growth. In this review we outlined the current knowledge regarding the implications of pyroptosis in gastrointestinal cancers.
Funder
National Key Research and Development Program of China