Establishment and validation of symptomatic patients colorectal screening score for predicting colorectal neoplasia risk

Author:

Wang Xu1ORCID,Zhang Xi2,Liu Jiani1,Liu Tian Yu1,Wang Bang Mao1,Liu Wen Tian1,Xu Xin1,Zhang Jie3,Cao Hai Long1ORCID

Affiliation:

1. Tianjin Key Laboratory of Digestive Diseases, Department of Gastroenterology and Hepatology Tianjin Institute of Digestive Diseases, National Key Clinical Specialty, General Hospital, Tianjin Medical University Tianjin China

2. Graduate School of Tianjin Medical University Tianjin China

3. Department of Gastroenterology Tianjin Medical University General Hospital Airport Hospital Tianjin China

Abstract

ObjectivesCurrently, most colorectal neoplasia (CRN) screening strategies target asymptomatic individuals. However, studies on patients with non‐specific gastrointestinal symptoms (NSGS) are limited. We aimed to develop a CRN risk score specifically for patients with NSGS.MethodsWe prospectively enrolled patients who underwent initial colonoscopy between June 2020 and June 2021. A new risk scoring system was constructed and its applicability was evaluated.ResultsA total of 1522 consecutive patients were enrolled, among whom 1016 symptomatic patients were randomly divided into a training cohort and a validation cohort at a ratio of 7:3. The constructed Symptomatic Patients Colorectal Screening (SPCS) score showed higher diagnostic efficacy and sensitivity than several previous scoring systems. Using the SPCS score, the patients were divided into a low‐risk group (−2 to 3 points) and a high‐risk group (4–10 points) for CRN. Additionally, the detection rate of CRN in the training and validation cohorts of the high‐risk group were 41.7% and 37.0%, respectively. The SPCS score detected 79.3% (188/237) of CRN and 87.5% (42/48) of advanced CRN in the high‐risk group, which reduced the workload of colonoscopy to 45.9% (466/1016).ConclusionAn effective CRN risk scoring system was established and validated for symptomatic patients, which accurately classified individuals into low‐risk and high‐risk groups for CRN and might be used to optimize colonoscopic resource allocation.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Wiley

Subject

Gastroenterology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3