Pharmacokinetic and Drug–Drug Interaction Profiles of the Combination of Tezacaftor/Ivacaftor

Author:

Garg Varun1,Shen Jinshan2,Li Chonghua1,Agarwal Sagar3,Gebre Asfiha1,Robertson Sarah1,Huang Jiayin4,Han Linda1,Jiang Licong5,Stephan Kristin1,Wang Linda T.1,Lekstrom‐Himes Julie1

Affiliation:

1. Vertex Pharmaceuticals Incorporated Boston Massachusetts USA

2. Gossamer Bio San Diego California USA

3. Alnylam Pharmaceuticals Cambridge Massachusetts USA

4. Astellas Pharma Global Development, Inc. Northbrook Illinois USA

5. Vertex Pharmaceuticals, Inc. San Diego California USA

Funder

Vertex Pharmaceuticals

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference9 articles.

1. Cystic Fibrosis Foundation.Cystic Fibrosis Foundation Patient Registry 2015 Annual Data Report(Cystic Fibrosis Foundation Bethesda MD 2016).

2. Cystic Fibrosis Trust.UK Cystic Fibrosis Registry 2015 Annual Data Report(Cystic Fibrosis Trust London UK 2016).

3. Symdeko [package insert].Boston MA:Vertex Pharmaceuticals Incorporated;2018.

4. Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del

5. Tezacaftor–Ivacaftor in Residual-Function Heterozygotes with Cystic Fibrosis

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