Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation-Reference-Cited by-同舟云学术

Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation

Published:2022-05-22 Issue:6 Volume:21 Page:
ISSN:1474-9718
Container-title:Aging Cell
language:en
Short-container-title:Aging Cell

Author:

Zhong Weizhe¹²³,Rao Zhuqing⁴,Xu Jian¹²³,Sun Yu¹²³,Hu Haoran¹²³,Wang Ping¹²³,Xia Yongxiang¹²³,Pan Xiongxiong⁴,Tang Weiwei¹²³,Chen Ziyi¹²³,Zhou Haoming¹²³,Wang Xuehao¹²³^ORCID

Affiliation:

1. Hepatobiliary/Liver Transplantation Center The First Affiliated Hospital of Nanjing Medical University Nanjing China

2. Key Laboratory of Liver Transplantation Chinese Academy of Medical Sciences Nanjing China

3. NHC Key Laboratory of Living Donor Liver Transplantation Nanjing Medical University Nanjing China

4. Department of Anesthesiology The First Affiliated Hospital with Nanjing Medical University Nanjing China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Six Talent Peaks Project in Jiangsu Province

Publisher

Wiley

Subject

Cell Biology,Aging

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.13622

Reference49 articles.

1. Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

2. cGAS in action: Expanding roles in immunity and inflammation

3. DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

4. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

5. Investigating mitochondrial autophagy by routine transmission electron microscopy: Seeing is believing?

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