Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxic<scp>CD8</scp><sup>+</sup>T cells boost cancer cell elimination-Reference-Cited by-同舟云学术

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Faster cytotoxicity with age: Increased perforin and granzyme levels in cytotoxicCD8⁺T cells boost cancer cell elimination

Published:2022-07-11 Issue:8 Volume:21 Page:
ISSN:1474-9718
Container-title:Aging Cell
language:en
Short-container-title:Aging Cell

Author:

Zöphel Dorina¹,Angenendt Adrian¹,Kaschek Lea¹,Ravichandran Keerthana²,Hof Chantal¹,Janku Sandra¹,Hoth Markus¹^ORCID,Lis Annette¹^ORCID

Affiliation:

1. Biophysics, Center for Integrative Physiology and Molecular Medicine School of Medicine, Saarland University Homburg Germany

2. Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, School of Medicine Saarland University Homburg Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Cell Biology,Aging

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.13668

Reference45 articles.

1. Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl‐2, and Bax. [Comparative Study];Aggarwal S.;Journal of Immunology,1998

2. Orai, STIM, and PMCA contribute to reduced calcium signal generation in CD8+ T cells of elderly mice

3. Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification, and modulation of apoptosis, necrosis, and mixed forms

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