Polycythaemia-inducing mutations in the erythropoietin receptor (EPOR): mechanism and function as elucidated by epidermal growth factor receptor-EPOR chimeras

Author:

Gross Mor1,Ben-Califa Nathalie1,McMullin Mary F.2,Percy Melanie J.2,Bento Celeste3,Cario Holger4,Minkov Milen5,Neumann Drorit1

Affiliation:

1. Department of Cell and Developmental Biology; Sackler Faculty of Medicine; Tel-Aviv University; Tel Aviv Israel

2. Department of Haematology; CCRCB; Queens University; Belfast UK

3. Department of Haematology; Centro Hospitalar e Universitário de Coimbra; Coimbra Portugal

4. Department of Paediatrics and Adolescent Medicine; University Medical Centre Ulm; Ulm Germany

5. Department of Haematology/Oncology; St. Anna Children's Hospital; Medical University of Vienna; Vienna Austria

Publisher

Wiley

Subject

Hematology

Reference47 articles.

1. A study of 36 unrelated cases with pure erythrocytosis revealed three new mutations in the erythropoietin receptor gene;Al-Sheikh;Haematologica,2008

2. Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase;Argetsinger;Cell,1993

3. Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins;Barber;Blood,1997

4. A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor beta-chain;Bazan;Biochemical and Biophysical Research Communications,1989

5. Molecular study of congenital erythrocytosis in 70 unrelated patients revealed a potential causal mutation in less than half of the cases (Where is/are the missing gene(s)?);Bento;European Journal of Haematology,2013

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