Affiliation:
1. Heart Institute Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA
2. Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA
3. Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA
4. Division of Bone Marrow Transplant Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA
5. Division of Pulmonary Medicine Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA
Abstract
AbstractBackgroundSurvival outcomes of children on extracorporeal membrane oxygenation (ECMO) at time of lung transplant (LTx) remain unclear.MethodsPediatric first‐time LTx recipients transplanted between January 2000 and December 2020 were identified in the United Network for Organ Sharing Registry to compare post‐transplant survival according to ECMO support at time of transplant. For a comprehensive analysis of the data, univariate analysis, multivariable Cox regression, and propensity score matching were performed.ResultsDuring the study period, 954 children under 18 years of age underwent LTx with 40 patients on ECMO. We did not identify a post‐LTx survival difference between patients receiving ECMO when compared to those that did not. A multivariable Cox regression model (Hazard ratio = 0.83; 95% confidence interval: 0.47, 1.45; p = .51) did not demonstrate an increased risk for death post‐LTx. Lastly, a propensity score matching analysis, retaining 33 ECMO and 33 non‐ECMO patients, further confirmed no post‐LTx survival difference comparing ECMO to no ECMO cohorts (Hazard ratio = 0.98; 95% confidence interval: 0.48, 2.00; p = .96).ConclusionsIn this contemporary cohort of children, the use of ECMO at the time of LTx did not negatively impact post‐transplant survival.
Funder
National Heart, Lung, and Blood Institute
National Institutes of Health
Subject
Transplantation,Pediatrics, Perinatology and Child Health
Cited by
1 articles.
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