Evaluation of height centile growth patterns compared with parental‐adjusted target height following kidney transplantation

Author:

Ng Natasha Su Lynn1,Gajendran Sellathurai1,Plant Nicholas1,Shenoy Mohan1

Affiliation:

1. Department of Paediatric Nephrology, Royal Manchester Children's Hospital Manchester UK

Abstract

AbstractBackgroundEarly steroid withdrawal (ESW) improves growth following kidney transplant (KT). It is not known whether these children achieve target height within mid‐parental height range post‐KT.MethodsRetrospective analysis of growth patterns of KT recipients following ESW in our center between 2009 and 2020 had minimum follow‐up period of 12 months.ResultsForty‐eight (female 29.2%) KT recipients, median age 5.3 years at first KT, were included. At KT, 29 (60.4%) recipients had normal height (SDS≥‐1.88) and in 23 (47.9%), the height was within their target height (parental‐adjusted height SDS within ±1.55). The proportion of children achieving normal height at 1‐, 2‐, 3‐, and 5‐years post‐KT (median 5.5 years) were 75%, 83.3%, 86.5%, and 88% respectively. The proportion of children achieving target height measured at the same intervals was 68.8%, 73.8%, 73%, and 80%, respectively. Children <6 years were most growth impaired at KT but were most likely to achieve target height within first‐year post‐KT (72%; p = .023). All 19 children with short stature at KT received dialysis. Three children received growth hormone post‐KT. Children who did not achieve target height post‐KT (n = 14), five had eGFR <60 mL/min/1.73 m2, and eight were on corticosteroid therapy at latest follow‐up.ConclusionsAlthough vast majority of children achieved normal height post‐KT following ESW during the first 5 years post‐KT, 20% of these children had not achieved their target height post‐KT.

Publisher

Wiley

Subject

Transplantation,Pediatrics, Perinatology and Child Health

Reference35 articles.

1. KDOQI clinical practice guideline for nutrition in children with CKD: 2008 update. Executive summary;Am J Kidney Dis,2009

2. National Institute for Health and Clinical E.Human growth hormone (somatropin) for the treatment of growth failure in children:Review of NICE Technology Appraisal Guidance 42.2010.

3. Growth after renal transplantation

4. Patterns of Growth after Kidney Transplantation among Children with ESRD

5. Clinical practice recommendations for growth hormone treatment in children with chronic kidney disease

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3