Alloantibody Responses After Renal Transplant Failure Can Be Better Predicted by Donor-Recipient HLA Amino Acid Sequence and Physicochemical Disparities Than Conventional HLA Matching

Author:

Kosmoliaptsis V.1,Mallon D. H.1,Chen Y.2,Bolton E. M.1,Bradley J. A.1,Taylor C. J.3

Affiliation:

1. Department of Surgery; University of Cambridge; Cambridge UK

2. Statistical Laboratory; Centre for Mathematical Sciences; University of Cambridge; Cambridge UK

3. Tissue Typing Laboratory; Cambridge University Hospitals; Cambridge UK

Funder

Cambridge National Institute for Health Research Biomedical Research Centre

NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation

Academy of Medical Sciences

Evelyn Trust

RCSEng Research Fellowship

Publisher

Wiley

Subject

Pharmacology (medical),Transplantation,Immunology and Allergy

Reference26 articles.

1. Impact of donor mismatches at individual HLA-A, -B, -C, -DR, and -DQ loci on the development of HLA-specific antibodies in patients listed for repeat renal transplantation;Kosmoliaptsis;Kidney Int,2014

2. High-resolution, three-dimensional modeling of human leukocyte antigen class I structure and surface electrostatic potential reveals the molecular basis for alloantibody binding epitopes;Kosmoliaptsis;Hum Immunol,2011

3. Predicting HLA class II alloantigen immunogenicity from the number and physiochemical properties of amino acid polymorphisms;Kosmoliaptsis;Transplantation,2011

4. Predicting HLA Class I alloantigen immunogenicity from the number and physiochemical properties of amino acid polymorphisms;Kosmoliaptsis;Transplantation,2009

5. Antibody-reactive epitope determination with HLAMatchmaker and its clinical applications;Duquesnoy;Tissue Antigens,2011

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