Complement C3 inhibitor Cp40 attenuates xenoreactions in pig hearts perfused with human blood

Author:

Abicht Jan-Michael1,Kourtzelis Ioannis2,Reichart Bruno3,Koutsogiannaki Sophia4,Primikyri Alexandra4,Lambris John D.4,Chavakis Triantafyllos2,Holdt Lesca5,Kind Alexander6,Guethoff Sonja7,Mayr Tanja1

Affiliation:

1. Department of Anaesthesiology; Ludwig Maximilian University; Munich Germany

2. Department of Clinical Pathobiochemistry; Medical Faculty; Technische Universität Dresden; Dresden Germany

3. Walter-Brendel-Centre; Ludwig Maximilian University; Munich Germany

4. Department of Pathology and Laboratory Medicine; University of Pennsylvania; Pennsylvania PA USA

5. Institute of Laboratory Medicine of Ludwig Maximilian University; Munich Germany

6. Chair of Livestock Biotechnology; School of Life Sciences Weihenstephan; Technical University of Munich; Munich Germany

7. Department of Cardiovascular Surgery; Ludwig Maximilian University; Munich Germany

Funder

Deutsche Forschungsgemeinschaft

Seventh Framework Programme

National Institutes of Health

Publisher

Wiley

Subject

Transplantation,Immunology

Reference36 articles.

1. Complement activation and coagulation in xenotransplantation;Cowan;Immunol Cell Biol,2009

2. Complement: a key system for immune surveillance and homeostasis;Ricklin;Nat Immunol,2010

3. Current status of xenotransplantation and prospects for clinical application;Pierson;Xenotransplantation,2009

4. Clinical xenotransplantation: the next medical revolution?;Ekser;Lancet,2012

5. Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library;Sahu;J Immunol,1996

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