A novel vaccine platform using glucan particles for induction of protective responses against Francisella tularensis and other pathogens

Author:

Abraham A1,Ostroff G1,Levitz S M1,Oyston P C F2ORCID

Affiliation:

1. University of Massachusetts Medical School, Worcester, Massachusetts, USA

2. CBR Division, Defence Science and Technology Laboratory, Porton Down, Salisbury, UK

Abstract

Summary Vaccines are considered the bedrock of preventive medicine. However, for many pathogens, it has been challenging to develop vaccines that stimulate protective, long-lasting immunity. We have developed a novel approach using β-1,3-D-glucans (BGs), natural polysaccharides abundantly present in fungal cell walls, as a biomaterial platform for vaccine delivery. BGs simultaneously provide for receptor-targeted antigen delivery to specialized antigen-presenting cells together with adjuvant properties to stimulate antigen-specific and trained non-specific immune responses. This review focuses on various approaches of using BG particles (GPs) to develop bacterial and fungal vaccine candidates. A special case history for the development of an effective GP tularaemia vaccine candidate is highlighted.

Funder

Defense Threat Reduction Agency

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Reference74 articles.

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