Characterisation of extracellular vesicles properties and <scp>miRNAs</scp> profiles in Brown Swiss milk-Reference-Cited by-同舟云学术

Characterisation of extracellular vesicles properties and miRNAs profiles in Brown Swiss milk

Published:2024-01-16 Issue:2 Volume:77 Page:273-281
ISSN:1364-727X
Container-title:International Journal of Dairy Technology
language:en
Short-container-title:Int J of Dairy Tech

Author:

Du Chunmei¹^ORCID,Quan Suyu²,Ma Jian¹,Yin Fuquan¹,Xu Mengsi³,Lin Liuxia³,Zhou Guangxian¹,Wu Jiang¹,Gan Shangquan¹³

Affiliation:

1. College of Coastal Agricultural Sciences Guangdong Ocean University Zhanjiang 524088 China

2. Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine Tianjin Agricultural University Tianjin 300392 China

3. State Key Laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation Sciences Shihezi 832000 China

Abstract

The conserved extracellular vesicles (EVs)‐miRNAs from milk might potentially influence human gene expression, or even introduce their analogous nucleotide chains into the human food chain. This study aimed to characterise the features of Brown Swiss milk EVs and the EVs‐miRNAs profile. Brown Swiss milk EVs exhibited a cup‐shaped morphology, with a distribution of (2.3 ± 0.8) E + 11 particles/mL. Sequencing identified a total of 238 miRNAs, which were mainly implicated in immune response and cell signal transduction. The conservation of these milk EVs‐miRNAs among species suggested they might be evolutionarily selected to regulate the growth and development of the newborns.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/1471-0307.13049

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