Fibrinolytic shutdown: fascinating theory but randomized controlled trial data are needed
Author:
Affiliation:
1. Clinical Trials Unit; London School of Hygiene & Tropical Medicine; London UK
Publisher
Wiley
Subject
Hematology,Immunology,Immunology and Allergy
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/trf.13490/fullpdf
Reference14 articles.
1. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial;Shakur;Lancet,2010
2. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial;Roberts;Lancet,2011
3. Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial;Roberts;Crit Care,2014
4. Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy;Chapman;J Trauma Acute Care Surg,2013
5. Postinjury fibrinolysis shutdown: rationale for selective tranexamic acid;Moore;J Trauma Acute Care Surg,2015
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