Comedonic lupus, a rare variant of chronic cutaneous lupus erythematosus (CCLE): case series and literature review

Abstract

AbstractBackgroundCutaneous lupus erythematosus (CLE) is an autoimmune disease with several clinical presentations. The chronic form predominantly presents as discoid rashes but may present with less common morphological findings that can sometimes make diagnosis difficult. Comedonic lupus is a rare and underdiagnosed variant, with unknown etiology and still poorly defined treatment.MethodsThe report illustrates a series of five cases of patients diagnosed with comedonic lupus, and it reviews 18 cases previously published in the literature.ResultsThe clinical presentation is of comedonal lesions, mostly located on the face, making a differential diagnosis with other benign conditions such as acne vulgaris, Favre‐Racouchot syndrome, and syringoma, emphasizing the importance of clinical practice and histopathology for diagnostic confirmation.ConclusionsThere is scarcity in the literature regarding the condition and therapeutic possibilities for these cases of comedonic lupus.