Serendipitous Discovery of a Prodrug of a PARP-1 Inhibitor
Author:
Affiliation:
1. Cephalon, Inc.; 145 Brandywine Parkway West Chester PA 19380-4245 USA
Publisher
Wiley
Subject
Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12165/fullpdf
Reference12 articles.
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2. New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs;Gibson;Nat Rev Mol Cell Biol,2012
3. Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression;Boehler;PNAS,2011
4. PARP inhibition: PARP1 and beyond;Rouleau;Nat Rev Cancer,2010
5. Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic;Ferraris;J Med Chem,2010
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