PLCγ1-PKCγ Signaling-Mediated Hsp90α Plasma Membrane Translocation Facilitates Tumor Metastasis

Author:

Yang Jian123,Song Xiaomin123,Chen Yang123,Lu Xin-an123,Fu Yan123,Luo Yongzhang123

Affiliation:

1. National Engineering Laboratory for Anti-tumor Protein Therapeutics; Tsinghua University; Beijing 100084 China

2. Beijing Key Laboratory for Protein Therapeutics; Tsinghua University; Beijing 100084 China

3. Cancer Biology Laboratory, School of Life Sciences; Tsinghua University; Beijing 100084 China

Funder

National Natural Science Foundation of China

Major Scientific and Technological Special Project for Significant New Drugs Creation

National Science & Technology Major Project

Ph.D. Programs Foundation for New Teachers of Ministry of Education of China

Publisher

Wiley

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology

Reference65 articles.

1. Targeting the dynamic HSP90 complex in cancer;Trepel;Nat Rev Cancer,2010

2. The chaperone Hsp90: changing partners for demanding clients;Rohl;Trends Biochem Sci,2013

3. HSP90 and the chaperoning of cancer;Whitesell;Nat Rev Cancer,2005

4. Altered Hsp90 function in cancer: a unique therapeutic opportunity;Bagatell;Mol Cancer Ther,2004

5. Hsp90 invades the outside;Picard;Nat Cell Biol,2004

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