Cowhage‐induced itch scores and the current perception threshold in assessing sensitive skin: An observational laboratory study

Author:

Zuo Ying1,Wan Ruoyu1,Jiang Ping2,Chen Xiaomei1,Li Li13,Hua Wei13

Affiliation:

1. Department of Dermatovenereology West China Hospital Sichuan University Chengdu China

2. Department of Radiology of West China Hospital China Huaxi MR Research Center (HMRRC) Sichuan University Chengdu China

3. Cosmetic Safety and Efficacy Evaluation Center West China Hospital Sichuan University Chengdu China

Abstract

AbstractBackgroundThe diagnosis of sensitive skin remains nonuniform, and the underlying mechanism is unclear. Previous studies were inconsistent in the current perception threshold (CPT) measurement for sensitive skin; thus, the neural sensitivity of sensitive skin needs to be clarified.ObjectivesThis study aimed to compare the CPT measurement and the cowhage test for sensitive skin and to investigate the correlation between CPT values and cowhage‐itch scores.MethodsParticipants with and without sensitive skin (n = 30, 30) were included. The cowhage test and CPT measurement with its related sensations were performed.ResultsNo difference was found in CPT between the sensitive and nonsensitive groups at either the site of the face or the forearm (5, 250, or 2000 Hz). Once the CPT was reached, sensations (itch, stinging, and throbbing) were significantly different between the two groups. Cowhage provoked more intense itch with a longer duration in the face (visual analog scale [VAS] score 1.90 ± 1.47 vs. 0.52 ± 0.90, p < 0.001; duration 3.80 ± 3.31 vs. 0.87 ± 1.43 min, p < 0.001) and forearm (VAS 2.53 ± 2.60 vs. 0.72 ± 1.06, p < 0.001; duration 3.37 ± 3.46 vs. 1.33 ± 2.14 min, p < 0.01) of the sensitive group compared with the nonsensitive group. Cowhage‐induced itch and CPT‐related itch (5 Hz) showed moderate correlations in both the face (r = 0.441, p < 0.001) and forearm (r = 0.491 p < 0.001) and weak correlations in the forearm (r = 0.323 at 250 Hz, p = 0.012; r = 0.376 at 2000 Hz, p = 0.003).ConclusionsCowhage test showed better performance in assessing the neural sensitivity of sensitive skin in comparison with the CPT measurement. Evaluation of CPT‐related sensations may add valuable information to sensitive skin assessment.

Funder

National Natural Science Foundation of China

Department of Science and Technology of Sichuan Province

Publisher

Wiley

Subject

Dermatology

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