Unveiling myeloid transformation: T‐LGLL with eosinophilia masking myeloid‐associated <scp><i>STAT5B</i></scp> mutation culminating in AML-Reference-Cited by-同舟云学术

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Unveiling myeloid transformation: T‐LGLL with eosinophilia masking myeloid‐associated STAT5B mutation culminating in AML

Published:2024-03-20 Issue:6 Volume:204 Page:2487-2491
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Dong Qianze¹,Wang Yang¹,Xiu Yan¹,Wu Xiaogang²,O'Neill Stacey³,Meyerson Howard³,Suske Tobias⁴,Moriggl Richard⁴,Hu Shimin⁵^ORCID,Wang Wei⁵^ORCID,Zhao Chen¹³⁶^ORCID

Affiliation:

1. Department of Pathology Case Western Reserve University Cleveland Ohio USA

2. Department of Genomic Medicine The University of Texas MD Anderson Cancer Center Houston Texas USA

3. Department of Pathology University Hospitals Cleveland Medical Center Cleveland Ohio USA

4. Institute of Animal Breeding and Genetics University of Veterinary Medicine Vienna Austria

5. Department of Hematopathology The University of Texas MD Anderson Cancer Center Houston Texas USA

6. Department of Medicine, Section of Hematology Louis Stokes Veterans Affairs Medical Center Cleveland Ohio USA

Funder

National Institutes of Health

U.S. Department of Veterans Affairs

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.19421

Reference14 articles.

1. STAT5b: A master regulator of key biological pathways

2. A STAT5B–CD9 axis determines self-renewal in hematopoietic and leukemic stem cells

3. Constitutive Activation of STAT5 by a Point Mutation in the SH2 Domain

4. Somatic STAT5b gain-of-function mutations in early onset nonclonal eosinophilia, urticaria, dermatitis, and diarrhea

5. STAT5BN642H is a driver mutation for T cell neoplasia

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