CYP3A activity in severe liver cirrhosis correlates with Child-Pugh and model for end-stage liver disease (MELD) scores

Author:

Albarmawi Albader1,Czock David1,Gauss Annika2,Ehehalt Robert2,Lorenzo Bermejo Justo3,Burhenne Jürgen1,Ganten Tom M.2,Sauer Peter2,Haefeli Walter E.1

Affiliation:

1. Department of Clinical Pharmacology and Pharmacoepidemiology; University of Heidelberg; Heidelberg Germany

2. Department of Internal Medicine IV, Gastroenterology, Infectious Diseases, and Intoxication; University Hospital Heidelberg; Heidelberg Germany

3. Institute of Medical Biometry and Informatics; University of Heidelberg; Heidelberg Germany

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference36 articles.

1. Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction;Verbeeck;Eur J Clin Pharmacol,2008

2. Dose adjustment in patients with liver disease;Delcò;Drug Saf,2005

3. Dosage adjustment for hepatic dysfunction based on Child-Pugh scores;Spray;Am J Health Syst Pharm,2007

4. Dosage adjustments in hepatic dysfunction;Amariles;Am J Health Syst Pharm,2007

5. Food and Drug Administration Guidance for industry. Pharmacokinetics in patients with impaired hepatic function: study design, data analysis, and impact on dosing and labeling 2003 http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm072123.pdf

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