Pharmacokinetic modeling and simulation support for age‐ and weight‐adjusted dosing of dabigatran etexilate in children with venous thromboembolism

Author:

Röshammar Daniel1,Huang Fenglei2,Albisetti Manuela3,Bomgaars Lisa4,Chalmers Elizabeth5,Luciani Matteo6,Halton Jacqueline7,Mitchell Lesley G.8,Bergstrand Martin1,Ibrahim Moustafa M. A.19,Joseph David2,Tartakovsky Igor10,Gropper Savion11,Brueckmann Martina1012,Brandão Leonardo R.1314ORCID

Affiliation:

1. Pharmetheus AB Uppsala Sweden

2. Translational Medicine and Clinical Pharmacology Boehringer Ingelheim Pharmaceuticals, Inc. Ridgefield Connecticut USA

3. Hematology Department University Children’s Hospital Zürich Switzerland

4. Department of Pediatrics Texas Children’s Cancer CenterBaylor College of Medicine Houston Texas USA

5. Department of Haematology Royal Hospital for Children, Glasgow Scotland United Kingdom

6. Pediatric Hematology/Oncology Department Pediatric Hospital Bambino Gesù Rome Italy

7. Department of Pediatrics, Children’s Hospital of Eastern Ontario University of Ottawa Ottawa Ontario Canada

8. Katz Group Centre for Research University of Alberta Edmonton Alberta Canada

9. Department of Pharmacy Practice Helwan University Cairo Egypt

10. Therapeutic Area Cardiovascular Medicine Boehringer Ingelheim International GmbH Ingelheim Germany

11. Therapeutic Area Inflammation Medicine Boehringer Ingelheim International GmbH Ingelheim Germany

12. Faculty of Medicine Mannheim of the University of Heidelberg Mannheim Germany

13. Department of Paediatrics The Hospital for Sick Children University of Toronto Toronto Ontario Canada

14. Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada

Publisher

Wiley

Subject

Hematology

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