Assessment of the long‐term efficacy and safety of adjunctive perampanel in tonic‐clonic seizures: Analysis of four open‐label extension studies

Author:

Rektor Ivan1ORCID,Krauss Gregory L.2ORCID,Inoue Yushi3,Kaneko Sunao4,Williams Betsy5,Patten Anna6,Malhotra Manoj7,Laurenza Antonio5,Wechsler Robert T.8ORCID

Affiliation:

1. Brno Epilepsy Center and Central European Institute of Technology (CEITEC) Masaryk University Brno Czech Republic

2. Department of Neurology Johns Hopkins University School of Medicine Baltimore Maryland USA

3. National Epilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders Shizuoka Japan

4. North Tohoku Epilepsy Center Minato Hospital Hachinohe Japan

5. Formerly: Eisai Inc. Woodcliff Lake New Jersey USA

6. Eisai Ltd. Hatfield UK

7. Eisai Inc. Woodcliff Lake New Jersey USA

8. Idaho Comprehensive Epilepsy Center Boise Idaho USA

Funder

Eisai Inc.

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Reference37 articles.

1. Food and Drug Administration.Fycompa® prescribing information. May 2019. Available at:https://www.fycompa.com/‐/media/Files/Fycompa/Fycompa_Prescribing_Information.pdf. Accessed May 11 2020.

2. European Medicines Agency.Fycompa® annex I: summary of product characteristics. April 2017. Available at:http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_‐_Product_Information/human/002434/WC500130815.pdf. Accessed May 11 2020.

3. Tolerability and safety of perampanel: two randomized dose-escalation studies

4. Adjunctive perampanel for refractory partial-onset seizures: Randomized phase III study 304

5. Evaluation of adjunctive perampanel in patients with refractory partial-onset seizures: Results of randomized global phase III study 305

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