Affiliation:
1. Department of Dermatology The People's Hospital of Baoshan Baoshan Yunnan China
2. Dermatology Service Veterans Affairs Medical Center San Francisco, and Department of Dermatology University of California San Francisco California USA
3. Department of Dermatology The First Affiliated Hospital of Soochow University Suzhou Jiangsu China
4. Dermatology Hospital Southern Medical University Guangzhou Guangdong 510091 China
Abstract
AbstractTwo serious health conditions, obesity and atopic dermatitis (AD), share some pathological features such as insulin resistance, leptin resistance and inflammation, and a growing body of evidence suggests a link between obesity and AD. Obesity predisposes an individual to and/or worsens AD, whereas AD increases the risk of obesity. Obesity and AD's interactions are mediated by cytokines, chemokines and immune cells. Obese individuals with AD are more resistant to anti‐inflammatory therapy, while weight loss can alleviate AD. In this review, we summarize the evidence linking AD and obesity. We also discuss the pathogenic role of obesity in AD, and vice versa. Because of the connection between these two conditions, mitigation of one could possibly prevent the development of or alleviate the other condition. Effective management of AD and weight loss can enhance the wellness of individuals with both of these conditions. However, proper clinical studies are warranted to validate this speculation.
Funder
National Institutes of Health
National Natural Science Foundation of China
Subject
Dermatology,Molecular Biology,Biochemistry
Cited by
12 articles.
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