Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications-Reference-Cited by-同舟云学术

Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications

Published:2016-07-15 Issue:1 Volume:120 Page:30-37
ISSN:1742-7835
Container-title:Basic & Clinical Pharmacology & Toxicology
language:en
Short-container-title:Basic Clin Pharmacol Toxicol

Author:

Nelson Leonard J.¹,Morgan Katie¹,Treskes Philipp¹,Samuel Kay²,Henderson Catherine J.³,LeBled Claire¹,Homer Natalie⁴,Grant M. Helen³,Hayes Peter C.¹,Plevris John N.¹

Affiliation:

1. Hepatology Laboratory; Royal Infirmary of Edinburgh; University of Edinburgh; Edinburgh UK

2. Scottish National Blood Transfusion Service; Research Development and Innovation Directorate; Cell Therapy Group; Edinburgh UK

3. Department of Biomedical Engineering; University of Strathclyde; Glasgow UK

4. Mass Spectrometry Core Laboratory; Wellcome Trust Clinical Research Facility; Queen's Medical Research Institute; Edinburgh UK

Funder

The Chief Scientist Office of Scotland

Biotechnology and Biological Sciences Research Council

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcpt.12631/fullpdf

Reference27 articles.

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3. Acetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture model;Nelson;Sci Rep,2015

4. In vitro evaluation of potential hepatotoxicity induced by drugs;Gómez-Lechón;Curr Pharm Des,2010

5. Artificial liver: a forth coming attraction;Sussman;Hepatology,1993

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