A Novel Scale Linking Potency and Dosage to Estimate Anticholinergic Exposure in Older Adults: the Muscarinic Acetylcholinergic Receptor ANTagonist Exposure Scale

Author:

Klamer Therese T.12,Wauters Maarten2,Azermai Majda2,Durán Carlos23,Christiaens Thierry2,Elseviers Monique24,Vander Stichele Robert2

Affiliation:

1. Division of Pharmacoepidemiology & Clinical Pharmacology; Utrecht Institute for Pharmaceutical Sciences; Utrecht University; Utrecht The Netherlands

2. Heymans Institute of Pharmacology; Clinical Pharmacology Research Unit; Ghent University; Ghent Belgium

3. Ecuadorian Center for Clinical Research, Health Information and Assessment (CIEC); Yachay Public Company; Quito Ecuador

4. Centre For Research and Innovation in Care (CRIC); University of Antwerp; Wilrijk Belgium

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Reference52 articles.

1. Waymire JC Acetylcholine Neurotransmission, Section 1, Chapter 11 http://nba.uth.tmc.edu/neuroscience/m/s1/chapter11.html

2. Association between prescribing of antimuscarinic drugs and antimuscarinic adverse effects in older people;Bostock;Expert Rev Clin Pharmacol,2010

3. Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study;Gray;JAMA Intern Med,2015

4. Anticholinergic drugs and negative outcomes in the older population: from biological plausibility to clinical evidence;Collamati;Aging Clin Exp Res,2016

5. Pharmacological approaches to targeting muscarinic acetylcholine receptors;Matera;Recent Pat CNS Drug Discov,2014

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