The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal NeuronsIn Vivo-Reference-Cited by-同舟云学术

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The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal NeuronsIn Vivo

Published:2016-08-23 Issue:1 Volume:120 Page:46-51
ISSN:1742-7835
Container-title:Basic & Clinical Pharmacology & Toxicology
language:en
Short-container-title:Basic Clin Pharmacol Toxicol

Author:

Hansen Henrik H.¹²,Weikop Pia³,Mikkelsen Maria D.²,Rode Frederik²,Mikkelsen Jens D.¹²

Affiliation:

1. Neurobiology Research Unit; Copenhagen University Hospital; Rigshospitalet Denmark

2. NeuroSearch A/S; Ballerup Denmark

3. Neuropsychiatric Laboratory; Copenhagen University Hospital; Rigshospitalet Denmark

Funder

Sundhed og Sygdom, Det Frie Forskningsråd

Danish Ministry of Science and Technology

Danish Strategic Research Council (Cognito)

Publisher

Wiley

Subject

Pharmacology,Toxicology,General Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcpt.12636/fullpdf

Reference38 articles.

1. Neuronal KCNQ potassium channels: physiology and role in disease;Jentsch;Nat Rev Neurosci,2000

2. K(v)7 channels: function, pharmacology and channel modulators;Dalby-Brown;Curr Top Med Chem,2006

3. KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle;Joshi;J Pharmacol Exp Ther,2009

4. Kv 7 positive modulators reduce detrusor overactivity and increase bladder capacity in rats;Svalo;Basic Clin Pharmacol Toxicol,2012

5. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness;Kubisch;Cell,1999

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1. Mouse models of Kcnq2 dysfunction;Epilepsia;2022-09-27

2. Behavior of KCNQ Channels in Neural Plasticity and Motor Disorders;Membranes;2022-05-06

3. ATP-sensitive Potassium Channel Subunits in Neuroinflammation: Novel Drug Targets in Neurodegenerative Disorders;CNS & Neurological Disorders - Drug Targets;2022-02

4. Heterozygous loss of epilepsy gene KCNQ2 alters social, repetitive and exploratory behaviors;Genes, Brain and Behavior;2019-07-31

5. Inhibition of striatal cholinergic interneuron activity by the Kv7 opener retigabine and the nonsteroidal anti-inflammatory drug diclofenac;Neuropharmacology;2018-07

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