High‐dose folic acid and cancer risk; unjustified concerns by von Wrede and colleagues regarding our paper-Reference-Cited by-同舟云学术

High‐dose folic acid and cancer risk; unjustified concerns by von Wrede and colleagues regarding our paper

Published:2023-07-24 Issue:9 Volume:64 Page:2244-2248
ISSN:0013-9580
Container-title:Epilepsia
language:en
Short-container-title:Epilepsia

Author:

Bjørk Marte‐Helene¹²^ORCID,Tomson Torbjörn³^ORCID,Dreier Julie Werenberg⁴^ORCID,Alvestad Silje¹⁵^ORCID,Gilhus Nils Erik¹²^ORCID,Gissler Mika⁶⁷^ORCID,Igland Jannicke⁸^ORCID,Leinonen Maarit K.⁶^ORCID,Sun Yuelian⁹^ORCID,Vegrim Håkon Magne¹^ORCID,Zoega Helga¹⁰¹¹^ORCID,Christensen Jakob¹²¹³^ORCID

Affiliation:

1. Department of Clinical Medicine University of Bergen Bergen Norway

2. Department of Neurology Haukeland University Hospital Bergen Norway

3. Department of Clinical Neuroscience Karolinska Institute Stockholm Sweden

4. National Centre for Register‐Based Research School of Business and Social Sciences Aarhus University Aarhus Denmark

5. National Centre for Epilepsy Oslo University Hospital Oslo Norway

6. Knowledge Brokers Finnish Institute for Health and Welfare Helsinki Finland

7. Institute of Molecular Medicine and Surgery Karolinska Institute Stockholm Sweden

8. Department of Global Public Health and Primary Care University of Bergen Bergen Norway

9. Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark

10. School of Population Health, Faculty of Medicine & Health University of New South Wales Sydney Australia

11. Centre of Public Health Sciences, Faculty of Medicine University of Iceland Reykjavik Iceland

12. Department of Neurology Aarhus University Hospital Aarhus Denmark

13. Department of Clinical Medicine Aarhus University Aarhus Denmark

Abstract

AbstractWomen using antiseizure medication in pregnancy are often advised to use high doses of folic acid supplements (1mg to 5 mg) to reduce the risk of teratogenicity. Recently, we published a report showing an association between maternal prescription fill of high dose folic acid in relation to pregnancy and childhood cancer in the offspring. The report has sparked a debate about which dose of folic acid that should be recommended in pregnancy in women in need of antiseizure medication. In this Commentary, we explain our findings and the method used in our report, and answer recent questions that have emerged.

Funder

NordForsk

Publisher

Wiley

Subject

Neurology (clinical),Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/epi.17717

Reference16 articles.

1. Cancer Risk in Children of Mothers With Epilepsy and High-Dose Folic Acid Use During Pregnancy

2. Unjustified allegation on cancer risks in children of mothers with epilepsy taking high‐dose folic acid during pregnancy‐No proof of a causal relationship;Wrede R;Epilepsia,2023

3. Benefits and Risks of Periconceptional Folic Acid Supplementation—Reply

4. The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening

5. Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability

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1. In reply: Why big data carries big potential rather than big trouble;Seizure: European Journal of Epilepsy;2023-10

2. Management of epilepsy in pregnancy: What we still need to learn;Epilepsy & Behavior Reports;2023