Synergy between 5-HT4 receptor stimulation and phosphodiesterase 4 inhibition in facilitating acetylcholine release in human large intestinal circular muscle

Author:

Pauwelyn V.1ORCID,Ceelen W.2,Lefebvre R. A.1

Affiliation:

1. Department of Pharmacology - Heymans Institute; Ghent University; Ghent Belgium

2. Department of Gastrointestinal Surgery; Ghent University Hospital; Ghent Belgium

Publisher

Wiley

Subject

Gastroenterology,Endocrine and Autonomic Systems,Physiology

Reference55 articles.

1. Basic and clinical pharmacology of new motility promoting agents;Galligan;Neurogastroenterol Motil,2005

2. The serotonin signaling system: from basic understanding to drug development-for functional GI disorders;Gershon;Gastroenterology,2007

3. Pharmacological characterization of a neuronal receptor for 5-hydroxytryptamine in guinea-pig ileum with properties similar to the 5-hydroxytryptamine-4 receptor;Craig;J Pharmacol Exp Ther,1990

4. 5-Hydroxytryptamine4 receptor agonists facilitate cholinergic transmission in the circular muscle of guinea-pig ileum - antagonism by tropisetron and dau-6285;Tonini;Life Sci,1992

5. Synergy between 5-HT4 receptor activation and acetylcholinesterase inhibition in human colon and rat forestomach;Cellek;Neurogastroenterol Motil,2008

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