Prevalence of hepatitis and <scp>HIV</scp> infection among 18‐months old children in Guinea‐Bissau before vaccination-Reference-Cited by-同舟云学术

Prevalence of hepatitis and HIV infection among 18‐months old children in Guinea‐Bissau before vaccination

Published:2024-08-26 Issue: Volume: Page:
ISSN:1360-2276
Container-title:Tropical Medicine & International Health
language:en
Short-container-title:Tropical Med Int Health

Author:

Dutschke Alexander¹²³,Agergaard Jane¹,Medina Candida²,Hønge Bo Langhoff¹²

Affiliation:

1. Department of Infectious Diseases Aarhus University Hospital Aarhus Denmark

2. Bandim Health Project Indepth Network Bissau Guinea‐Bissau

3. GloHAU, Center for Global Health, School of Public Health Aarhus University Aarhus Denmark

Abstract

AbstractObjectivesThis study reports on the prevalence of hepatitis B virus (HBV) in children in Guinea‐Bissau before the hepatitis B vaccine was introduced.MethodsCross‐sectional study. From 2005 to 2008, 187 children aged 18 months were enrolled in a vaccine trial and had blood samples taken to test for HBV (HbsAg, anti‐HBs and anti‐HBc), hepatitis C virus (HCV) and HIV.ResultsHBsAg prevalence was 11.2% and prevalence of any HBV serological marker was 16.0%. No children were positive for HCV. One was positive for HIV‐1.ConclusionsThe prevalence of HBsAg was high compared to other sub‐Saharan African countries pre‐immunisation, underscoring the importance of broad and sustained HBV vaccination. This study indicates that the majority of HBV transmission is horizontal during childhood in Guinea‐Bissau.

Funder

Aarhus Universitet

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/tmi.14045

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