Affiliation:
1. The 16th Department of Plastic Surgery Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College No.33 Badachu Road, Shijingshan District Beijing 100144 China
2. Department of Plastic and Cosmetic Surgery Tongji Hospital School of Medicine Tongji University Shanghai 200065 China
Abstract
AbstractBackgroundThe filling materials on the beauty market can be classified into three types: natural biological materials, synthetic polymer materials, and composites containing bioactive substances. However, comparative experimental data is lacking to compare their biological responses and permanence.AimsThe main object of this study was to evaluate the biological response of these three types of fillers to provide a theoretical basis for clinical application.MethodsSix‐week‐old female mice were injected subcutaneously with hyaluronic acid (HA) gel, calcium hydroxylapatite (CaHA) microspheres, and extracellular matrix (ECM) bio gel to observe the body reaction and permanence. At 1, 4, 8, and 16 weeks, the test sites were excised and analyzed by histopathology and proteomics.ResultsExtracellular matrix had a minimal foreign body response. HA had a good volume effect at the early stage but the volume retention rate was lower than CaHA in the long term. CaHA could stimulate neo‐collagen formation.ConclusionThis study has proven the effectiveness and safety of these fillers and could provide clinical guidance for the plastic surgeon.
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2 articles.
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