Open‐label, single‐arm, single‐center clinical study on the effectiveness and safety of a moisturizer containing tocotrienol‐rich composition in children with mild to moderate atopic dermatitis

Author:

How Kang Nien1,Chang Hon Weng2,Lai Oi Ming34

Affiliation:

1. Dermatology Unit, Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang Malaysia

2. Lipidware Sdn. Bhd., G‐05, Jalan Maklumat, MTDC‐UPM Universiti Putra Malaysia Serdang Malaysia

3. Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences Universiti Putra Malaysia Serdang Malaysia

4. Institute of Bioscience Universiti Putra Malaysia Serdang Malaysia

Abstract

AbstractBackgroundLittle is known about antioxidant efficacy of topical vitamin E on atopic dermatitis (AD) due to lack of controlled clinical studies.AimThe study evaluates the effectiveness and safety of a topical moisturizer containing tocotrienol‐rich composition over 12 weeks on patients aged between 1 month and 12 years with mild to moderate AD.MethodsWe conducted a 12 weeks, prospective, open‐label clinical study on the effect of tocotrienol as an adjunct to conventional treatment. This study was approved by the Ethics Committee for Research Involving Human Subject. JKEUPM‐2019‐274 (NMMR‐19‐1588‐49234).ResultsThirty AD patients with a mean age of 2.77 ± 3.05 were enrolled in the study. At week‐12, significant reduction of investigator global assessment (63.4%), Patient‐Oriented Scoring Atopic Dermatitis Index (PO‐SCORAD) (65%), and SCORAD (52.3%) was noted (p < 0.05). There was also a significant decreased in pruritus intensity (46%, p < 0.05). Similarly at week‐12, Infant's Dermatitis Quality of Life Index and Children's Dermatology Life Quality Index were found to improve significantly compared to baseline (p < 0.05). Instrumental assessment revealed improvement in TEWL and erythema index, 49.7% and 17.4%, respectively. No adverse reaction was observed. 95% of patients were satisfied with the moisturizer and 90% perceived it to be better than the one in the market. There was a 55.07% reduction in the use of hydrocortisone 1% cream toward the end of the study (p < 0.05).ConclusionsThe results suggested that tocotrienol‐rich moisturizer is safe and effective in the management of AD in young children.

Publisher

Wiley

Subject

Dermatology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3