Phosphodiesterase-3B-cAMP Pathway of Leptin Signalling in the Hypothalamus is Impaired During the Development of Diet-Induced Obesity in FVB/N Mice

Author:

Sahu M.1,Anamthathmakula P.1,Sahu A.12

Affiliation:

1. Department of Obstetrics, Gynecology and Reproductive Sciences; Magee-Womens Research Institute; University of Pittsburgh School of Medicine; Pittsburgh PA USA

2. Department of Cell Biology; University of Pittsburgh School of Medicine; Pittsburgh PA USA

Funder

NIH RO1

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Endocrine and Autonomic Systems,Endocrinology,Endocrinology, Diabetes and Metabolism

Reference53 articles.

1. Diet-induced obese mice develop peripheral, but not central, resistance to leptin;Van Heek;J Clin Invest,1997

2. Defense of differing body weight set points in diet-induced obese and resistant rats;Levin;Am J Physiol,1998

3. Positional cloning of the mouse obese gene and its human homologue;Zhang;Nature,1994

4. Leptin and the regulation of body weight in mammals;Friedman;Nature,1998

5. Serum immunoreactive-leptin concentrations in normal-weight and obese humans;Considine;N Engl J Med,1996

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