Co‐development of a school‐based and primary care‐based multicomponent intervention to improve HPV vaccine coverage amongst French adolescents (the PrevHPV Study)

Author:

Bocquier Aurélie1ORCID,Bruel Sébastien23,Michel Morgane45,Le Duc‐Banaszuk Anne‐Sophie6,Bonnay Stéphanie1,Branchereau Marion6,Chevreul Karine45,Chyderiotis Sandra7,Gauchet Aurélie89,Giraudeau Bruno1011,Hagiu Dragos‐Paul212,Mueller Judith E.713,Gagneux‐Brunon Amandine14,Thilly Nathalie115,

Affiliation:

1. APEMAC Université de Lorraine Nancy France

2. Department of General Practice, Jacques Lisfranc Faculty of Medicine Saint‐Etienne‐Lyon University Saint‐Etienne France

3. Health, Systemic, Process UR 4129 Research Unit, University Claude Bernard University of Lyon Lyon France

4. ECEVE UMR 1123, Université de Paris Cité Paris France

5. Assistance Publique‐Hôpitaux de Paris, Hôtel Dieu, URC Eco Ile‐de‐France/Hôpital Robert Debré Unité d'épidémiologie clinique Paris France

6. Centre Régional de Coordination des Dépistages des cancers‐Pays de la Loire Angers France

7. Emerging Disease Epidemiology Unit, Institut Pasteur Université Paris Cité Paris France

8. LIP/PC2S Université Grenoble Alpes Grenoble France

9. LIP/PC2S Université Savoie Mont Blanc Chambéry France

10. SPHERE U1246, Université de Tours, Université de Nantes INSERM Tours France

11. INSERM CIC 1415 CHRU de Tours Tours France

12. CIC‐INSERM 1408, CHU de Saint‐Etienne France

13. Univ. Rennes, EHESP, CNRS, Inserm, Arènes ‐ UMR 6051 RSMS (Recherche sur les Services et Management en Santé) ‐ U 1309 Rennes France

14. Centre International de Recherche en Infectiologie, Team GIMAP, Univ Lyon, Université Jean Monnet, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530, CIC INSERM 1408 Vaccinologie CHU de Saint‐Etienne Saint‐Etienne France

15. Département Méthodologie, Promotion, Investigation Université de Lorraine, CHRU‐Nancy Nancy France

Abstract

AbstractIntroductionDespite various efforts to improve human papillomavirus (HPV) vaccine coverage in France, it has always been lower than in most other high‐income countries. The health authorities launched in 2018 the national PrevHPV research programme to (1) co‐develop with stakeholders and (2) evaluate the impact of a multicomponent complex intervention aimed at improving HPV vaccine coverage amongst French adolescents.ObjectiveTo describe the development process of the PrevHPV intervention using the GUIDance for rEporting of intervention Development framework as a guide.MethodsTo develop the intervention, we used findings from (1) published evidence on effective strategies to improve vaccination uptake and on theoretical frameworks of health behaviour change; (2) primary data on target populations' knowledge, beliefs, attitudes, preferences, behaviours and practices as well as the facilitators and barriers to HPV vaccination collected as part of the PrevHPV Programme and (3) the advice of working groups involving stakeholders in a participatory approach. We paid attention to developing an intervention that would maximise reach, adoption, implementation and maintenance in real‐world contexts.ResultsWe co‐developed three components: (1) adolescents' and parents' education and motivation using eHealth tools (web conferences, videos, and a serious video game) and participatory learning at school; (2) general practitioners' e‐learning training on HPV using motivational interviewing techniques and provision of a decision aid tool and (3) easier access to vaccination through vaccination days organised on participating middle schools' premises to propose free of charge initiation of the HPV vaccination.ConclusionWe co‐developed a multicomponent intervention that addresses a range of barriers and enablers of HPV vaccination. The next step is to build on the results of its evaluation to refine it before scaling it up if proven efficient. If so, it will add to the small number of multicomponent interventions aimed at improving HPV vaccination worldwide.Patient or Public ContributionThe public (adolescents, their parents, school staff and health professionals) participated in the needs assessment using a mixed methods approach. The public was also involved in the components' development process to generate ideas about potential activities/tools, critically revise the successive versions of the tools and provide advice about the intervention practicalities, feasibility and maintenance.

Publisher

Wiley

Subject

Public Health, Environmental and Occupational Health

Reference65 articles.

1. WHO. Human papillomavirus (HPV) and cervical cancer. February 22  2022. Accessed November 8 2022.https://www.who.int/news-room/fact-sheets/detail/human-papillomavirus-(hpv)-and-cervical-cancer

2. Human papillomavirus vaccines: WHO position paper, May 2017;WHO;Weekly Epidemiol Rec,2017

3. IARC WHO. The Global Cancer Observatory—World. Source: Globocan 2020. March2021. Accessed November 8 2022.https://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf

4. IARC WHO. The Global Cancer Observatory—France. Source: Globocan 2020. March2021. Accessed November 8 2022.https://gco.iarc.fr/today/data/factsheets/populations/250-france-fact-sheets.pdf

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