Solubility of chiral species as function of the enantiomeric excess

Author:

Coquerel Gerard1

Affiliation:

1. Normandie Université, Crystal Genesis Unit SMS EA3233 IMR 4114, 1 Rue Tresniere Université de Rouen, Mont Saint Aignan CEDEX, France

Abstract

Abstract The solubility of racemizable and nonracemizable chiral species is discussed in terms of: enantiomeric excess, nature of solvent and the solid phases, which are in equilibrium with a saturated solution. Stable and metastable equilibria are contemplated by an extensive used of phase diagrams.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Reference44 articles.

1. Processes to separate enantiomers;Lorenz;Angew. Chem.Int. Ed.,2014

2. Z. Phys. Chem. 1897, 119, 227. Cited in: Rein ten Wolde, P., Frenkel, D., Homogeneous nucleation and the Ostwald step rule;Ostwald;Phys Chem Chem Phys,1999

3. Modification of the phase rule for optical enantiomers and other symmetric systems;Scott;J Chem Soc,1977

4. The Nanoscale Aspects of Chirality in Crystal Growth: Structure and Heterogeneous Equilibria;Coquerel,2009

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