Treatment trends in patients with de novo metastatic prostate cancer in the era of upfront combination therapy

Author:

Miura Hikari1,Hatakeyama Shingo1ORCID,Tabata Ryuji2ORCID,Fujimori Daiji2,Kawashima Yohei2,Moriyama Shingo2,Oishi Takuya1,Horiguchi Hirotaka1,Soma Osamu3,Noro Daisuke4,Tanaka Toshikazu5,Okamoto Teppei1ORCID,Yamamoto Hayato1,Sato Satoshi3,Ohyama Chikara6

Affiliation:

1. Department of Urology Hirosaki University School of Medicine Hirosaki Japan

2. Department of Urology Ageo Central General Hospital Ageo Japan

3. Department of Urology Odate Municipal Hospital Odate Japan

4. Department of Urology Mutsu General Hospital Mutsu Japan

5. Department of Urology Aomori Prefectural Central Hospital Aomori Japan

6. Department of Advanced Transplant and Regenerative Medicine Hirosaki University School of Medicine Hirosaki Japan

Abstract

ObjectivesThe objective of this study is to assess the trends in treatment selection for patients with de novo metastatic castration‐sensitive prostate cancer in the era of upfront combination therapy.MethodsThis multicenter retrospective study included 595 patients treated with either upfront combination therapy (upfront novel hormonal therapies and taxane‐based chemotherapy) or vintage therapy (androgen deprivation therapy with or without bicalutamide) between 2016 and 2021. High tumor burden metastatic disease was defined when a patient met the CHAARTED or LATITUDE criteria. We evaluated trends in treatment selection and reasons for selecting vintage therapy.ResultsOf the 595, 123 and 472 patients were classified as having low and high tumor‐burden disease, respectively. The Use of upfront combination therapy was found to be rapidly increasing with utilization rates of 72% and 54% in 2021 for high and low tumor‐burden disease, respectively. Multivariable logistic regression analysis found older age, poor performance status, and nonacademic center were significantly associated with the selection of vintage therapy. Of the 163 patients who received vintage hormone therapy after approval of upfront therapy, 74.2% had a specific reason for avoiding upfront therapy. The reasons for selecting vintage therapy included refusal (39.8%), older age (67.6%), frailty (56.3%), and comorbidity (40.8%). Furthermore, 16.9% of patients declined upfront combination therapy due to cost concerns.ConclusionUpfront combination therapy use has 72% and 54% prevalence among patients with high and low tumor burden diseases, respectively, in this current practice. Older age, poor performance status, and facility bias were negatively associated with the use of upfront combination therapy.

Publisher

Wiley

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