Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studies
Author:
Affiliation:
1. Rigel Pharmaceuticals, Inc.; South San Francisco; CA; USA
2. Quintiles Drug Research Unit at Guy's Hospital; London; UK
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bcp.12048/fullpdf
Reference24 articles.
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2. Src and Syk kinases: key regulators of phagocytic cell activation;Berton;Trends Immunol,2005
3. Fcγ receptors: old friends and new family members;Nimmerjahn;Immunity,2006
4. Spleen tyrosine kinase (SYK) biology, inhibitors and therapeutic applications;Singh;Annu Rep Med Chem,2007
5. Targeting Syk as a treatment for allergic and autoimmune disorders;Wong;Expert Opin Investig Drugs,2004
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