Regression of Metastatic Liver Tumors in Rats Treated with Angiogenesis Inhibitor TNP-470: Occurrence of Apoptosis and Necrosis

Author:

Ahmed Motahar H.,Aral Tomio,Konno Hiroyuki,Nahar Lutfun,Tanaka Tatsuro,Izumiyama Naotaka,Takubo Kaiyo,Nakamura Satoshi,Baba Shozo

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference16 articles.

1. Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo;Yanase;Cancer Res.,1993

2. Comparison of the inhibitory effect of the angiogenesis inhibitor, TNP-470, and mitomycin C on the growth and liver metastasis of humancoloncancer;Konno;Int.J. Cancer,1995

3. The angiogenesis inhibitor TNP-470 (AGM-470) improves long-term survival of rats with liver metastasis;Ahmed;J. Surg. Res.,1996

4. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth;Ingber;Nature,1990

5. AGM-470, a potent angiogenesis inhibitor, prevents the entry of normal but not transformed endothelial cells into the G1 phase of the cell cycle;Antonie;Cancer Res.,1994

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