Phase II study of dose-modified busulfan by real-time targeting in allogeneic hematopoietic stem cell transplantation for myeloid malignancy

Author:

Kuwatsuka Yachiyo,Kohno Akio1,Terakura Seitaro2,Saito Shigeki,Shimada Kazuyuki,Yasuda Takahiko,Inamoto Yoshihiro,Miyamura Koichi3,Sawa Masashi4,Murata Makoto2,Karasuno Takahiro5,Taniguchi Shuichi6,Nagafuji Koji7,Atsuta Yoshiko8,Suzuki Ritsuro8,Fukumoto Mariko9,Naoe Tomoki2,Morishita Yoshihisa1,

Affiliation:

1. Department of Hematology and Oncology; JA Aichi Konan Kosei Hospital; Konan; Japan

2. Department of Hematology and Oncology; Nagoya University Graduate School of Medicine; Nagoya; Japan

3. Department of Hematology; Japanese Red Cross Nagoya First Hospital; Nagoya; Japan

4. Department of Hematology and Oncology; Anjo Kosei Hospital; Anjo; Japan

5. Department of Hematology and Oncology; Osaka Medical Center for Cancer and Cardiovascular Diseases; Osaka; Japan

6. Department of Hematology; Toranomon Hospital; Tokyo; Japan

7. Department of Medicine and Biosystemic Science; Kyushu University Graduate School of Medical Sciences; Fukuoka; Japan

8. Department of Hematopoietic Stem Cell Transplantation Data Management; Nagoya University School of Medicine; Nagoya; Japan

9. Division of Toxicology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences; Kitasato University; Tokyo; Japan

Publisher

Wiley

Subject

Cancer Research,Oncology,General Medicine

Reference31 articles.

1. Bone marrow transplantation for leukemia following a new busulfan and cyclophosphamide regimen;Tutschka;Blood,1987

2. Busulfan plus cyclophosphamide compared with total-body irradiation plus cyclophosphamide before marrow transplantation for myeloid leukemia: long-term follow-up of 4 randomized studies;Socie;Blood,2001

3. Marrow transplantation for chronic myeloid leukemia: the influence of plasma busulfan levels on the outcome of transplantation;Slattery;Blood,1997

4. Association of busulfan area under the curve with veno-occlusive disease following BMT;Dix;Bone Marrow Transplant,1996

5. Dose-dependent neurotoxicity of high-dose busulfan in children: a clinical and pharmacological study;Vassal;Cancer Res,1990

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