Arecoline downregulates levels of p21 and p27 through the reactive oxygen species/mTOR complex 1 pathway and may contribute to oral squamous cell carcinoma

Author:

Ji Wen-Tsai1,Yang Sheng-Ru1,Chen Jeff Yi-Fu2,Cheng Ya-Ping1,Lee Ying-Ray,Chiang Ming-Ko1,Chen Hau-Ren1

Affiliation:

1. Department of Life Science; Institute of Molecular Biology and Institute of Biomedical Science; College of Science; National Chung Cheng University; Min-Hsiung; Chia-Yi; Taiwan

2. Department of Biotechnology; Kaohsiung Medical University; Kaohsiung; Taiwan

Publisher

Wiley

Subject

Cancer Research,Oncology,General Medicine

Reference62 articles.

1. Global cancer statistics;Jemal;CA Cancer J Clin,2011

2. Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan;Chen;Oral Oncol,1999

3. Arecoline induced cell cycle arrest, apoptosis, and cytotoxicity to human endothelial cells;Tseng;Clin Oral Investig,2011

4. Arecoline-mediated inhibition of AMP-activated protein kinase through reactive oxygen species is required for apoptosis induction;Yen;Oral Oncol,2011

5. Induction of shape abnormality and unscheduled DNA synthesis by arecoline in the germ cells of mice;Sinha;Mutat Res,1985

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