Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors

Author:

Minakata Kunihiko,Takahashi Fumiyuki,Nara Takeshi1,Hashimoto Muneaki1,Tajima Ken,Murakami Akiko,Nurwidya Fariz,Yae Suzu,Koizumi Fumiaki2,Moriyama Hiroyuki3,Seyama Kuniaki,Nishio Kazuto4,Takahashi Kazuhisa

Affiliation:

1. Department of Molecular and Cellular Parasitology; School of Medicine; Juntendo University; Tokyo; Japan

2. Shien-Lab; National Cancer Center Hospital; Tokyo; Japan

3. Pharmaceutical Research and Technology Institute; School of Medicine; Kinki University; Osaka; Japan

4. Department of Genome Biology; School of Medicine; Kinki University; Osaka; Japan

Publisher

Wiley

Subject

Cancer Research,Oncology,General Medicine

Reference28 articles.

1. Cancer statistics, 2010;Jemal;CA Cancer J Clin,2010

2. Epidermal growth factor receptor expression correlates with poor prognosis in non-small cell lung cancer patients with p53 overexpression;Ohsaki;Oncol Rep,2000

3. Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis;Hirsch;J Clin Oncol,2003

4. Epidermal growth factor receptor mutations in lung cancer;Sharma;Nat Rev Cancer,2007

5. Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung;Rusch;Cancer Res,1993

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