Genotype-directed, dose-finding study of irinotecan in cancer patients with UGT1A1*28 and/or UGT1A1*6 polymorphisms

Author:

Satoh Taroh,Ura Takashi,Yamada Yasuhide,Yamazaki Kentaro,Tsujinaka Toshimasa,Munakata Masaki,Nishina Tomohiro,Okamura Shu,Esaki Taito,Sasaki Yasutsuna,Koizumi Wasaburo,Kakeji Yoshihiro,Ishizuka Naoki,Hyodo Ichinosuke,Sakata Yuh

Publisher

Wiley

Subject

Cancer Research,Oncology,General Medicine

Reference27 articles.

1. Clinical pharmacokinetics and metabolism of irinotecan (CPT-11);Mathijssen;Clin Cancer Res,2001

2. Lessons learned from the irinotecan metabolic pathway;Ma;Curr Med Chem,2003

3. Irinotecan pathway genotype analysis to predict pharmacokinetics;Mathijssen;Clin Cancer Res,2003

4. Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan;Innocenti;J Clin Oncol,2004

5. UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer;Marcuello;Br J Cancer,2004

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