Polydopamine‐curcumin coating of titanium for remarkable antibacterial activity via synergistic photodynamic and photothermal properties

Abstract

AbstractCombined photothermal therapy (PTT) and photodynamic therapy (PDT) has emerged as a novel and effective antibacterial strategy. In order to endow titanium (Ti) with antibacterial properties, the Ti‐PDA‐Cur composite was prepared using the excellent adhesion properties of polydopamine (PDA) to load curcumin (Cur) on the surface of Ti. The Ti‐PDA‐Cur coating can produce singlet oxygen (1O2) and heat under 405 + 808 nm light irradiation, which can effectively kill Staphylococcus aureus and Escherichia coli. Moreover, the cytotoxicity and hemolysis rate of Ti‐PDA‐Cur were low, indicating its good biocompatibility. Therefore, this study provided a new strategy for the development of new Ti implants.