The quest for new robust bacterial monoamine oxidases

Abstract

Microbial enzymes are versatile, cost‐effective, and sustainable tools, making them a preferred choice for enzymatic processes. Santema et al. harnessed AlphaFold, a cutting‐edge structure prediction tool, to discover new thermophilic monoamine oxidases (MAO) that could be relevant for drug development and use in biotechnology fields. The new enzyme displays thermal robustness, offering a unique structure‐to‐function profile compared to known MAOs. This bacterial enzyme, paired with recent advancements in enzyme engineering, has the potential to meet the biotech sector's need for customized enzymes.