Synthesis of Naphthyl-, Quinolin- and Anthracenyl Analogues of Clofibric Acid as PPARαAgonists

Author:

Giampietro Letizia1,Ammazzalorso Alessandra1,Bruno Isabella1,Carradori Simone1,De Filippis Barbara1,Fantacuzzi Marialuigia1,Giancristofaro Antonella1,Maccallini Cristina1,Amoroso Rosa1

Affiliation:

1. Dipartimento di Farmacia; Università “G. d'Annunzio” di Chieti; via dei Vestini 66100 Chieti Italy

Funder

Università degli Studi G. d'Annunzio Chieti - Pescara

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference24 articles.

1. The mechanisms of action of PPARs;Berger;Annu Rev Med,2002

2. PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation;Varga;Biochim Biophys Acta,2011

3. Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease;Pawlak;J Hepatol,2015

4. Fibrates and future PPARalpha agonists in the treatment of cardiovascular disease;Staels;Nat Clin Pract Cardiovasc Med,2008

5. PPARγ ligands and their therapeutic applications: a patent review (2008-2014);Takada;Expert Opin Ther Pat,2015

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