Peripheral nervous system and neuromuscular disorders in the emergency department: A review

Author:

Sivadasan Ajith1ORCID,Cortel‐LeBlanc Miguel A.2345,Cortel‐LeBlanc Achelle3456,Katzberg Hans1

Affiliation:

1. Ellen & Martin Prosserman Centre for Neuromuscular Diseases Toronto General Hospital, University Health Network, University of Toronto Toronto Ontario Canada

2. Department of Emergency Medicine Queensway Carleton Hospital Ottawa Ontario Canada

3. Faculty of Medicine University of Ottawa Ottawa Ontario Canada

4. Institut du Savoir Montfort Ottawa Ontario Canada

5. 360 Concussion Care Ottawa Ontario Canada

6. Division of Neurology, Department of Medicine Queensway Carleton Hospital Ottawa Ontario Canada

Abstract

AbstractIntroductionAcute presentations and emergencies in neuromuscular disorders (NMDs) often challenge clinical acumen. The objective of this review is to refine the reader's approach to history taking, clinical localization and early diagnosis, as well as emergency management of neuromuscular emergencies.MethodsAn extensive literature search was performed to identify relevant studies. We prioritized meta‐analysis, systematic reviews, and position statements where possible to inform any recommendations.SummaryThe spectrum of clinical presentations and etiologies ranges from neurotoxic envenomation or infection to autoimmune disease such as Guillain–Barré Syndrome (GBS) and myasthenia gravis (MG). Delayed diagnosis is not uncommon when presentations occur “de novo,” respiratory failure is dominant or isolated, or in the case of atypical scenarios such as GBS variants, severe autonomic dysfunction, or rhabdomyolysis. Diseases of the central nervous system, systemic and musculoskeletal disorders can mimic presentations in neuromuscular disorders.ConclusionsFortunately, early diagnosis and management can improve prognosis. This article provides a comprehensive review of acute presentations in neuromuscular disorders relevant for the emergency physician.

Publisher

Wiley

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