Addressing the rising trend of high‐risk pulmonary embolism mortality: Clinical and research priorities

Author:

Casey Scott D.123ORCID,Stubblefield William B.4ORCID,Luijten Dieuwke5,Klok Frederikus A.5,Westafer Lauren M.67,Vinson David R.128ORCID,Kabrhel Christopher9ORCID

Affiliation:

1. Kaiser Permanente Division of Research, Oakland California USA

2. The Kaiser Permanente CREST Network, Oakland California USA

3. Department of Emergency Medicine, Kaiser Permanente Vallejo Medical Center, Vallejo California USA

4. Department of Emergency Medicine Vanderbilt University Medical Center Nashville TN USA

5. Department of Medicine – Thrombosis and Hemostasis Leiden University Medicine Center Leiden Netherlands

6. Department of Emergency Medicine UMASS Chan Medical School‐Baystate Springfield Massachusetts USA

7. Department of Healthcare Delivery and Population Science UMASS Chan Medical School‐Baystate Springfield Massachusetts USA

8. Department of Emergency Medicine, Kaiser Permanente Roseville Medical Center, Roseville California USA

9. Department of Emergency Medicine Harvard Medical School Boston Massachusetts USA

Abstract

AbstractDeaths from high‐risk pulmonary embolism (PE) appear to have increased in the last decade. Modifiable risks contributing to this worrisome trend present opportunities for physicians, researchers, and healthcare policymakers to reduce excess mortality. Emerging advanced therapies for PE appear promising, although we lack clear insight as to the magnitude of potential benefit and which patient subgroup(s) should receive them. Treatment and outcome disparities attributable to social determinants of health demand new healthcare delivery policy. In this article, we examine current PE epidemiology, suggest quality improvement and healthcare policy initiatives, and discuss relevant ongoing clinical trials aimed at addressing excess PE mortality.

Publisher

Wiley

Subject

Emergency Medicine,General Medicine

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