Activation of MT2 receptor ameliorates dendritic abnormalities in Alzheimer’s disease via C/EBPα/miR-125b pathway

Author:

Tang Hui12,Ma Mei12,Wu Ying12,Deng Man-Fei12,Hu Fan12,Almansoub Hasan.a.m.m.12,Huang He-Zhou12,Wang Ding-Qi12,Zhou Lan-Ting12,Wei Na34,Man Hengye5,Lu Youming2,Liu Dan26,Zhu Ling-Qiang12ORCID

Affiliation:

1. Department of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College; Huazhong University of Science and Technology; Wuhan China

2. The Institute of Brain Research, Collaborative Innovation Center for Brain Science; Huazhong University of Science and Technology; Wuhan China

3. Department of Pathology; The First Affiliated Hospital of Zhengzhou University; Zhengzhou China

4. Department of Pathology, School of Basic Medicine; Zhengzhou University; Zhengzhou China

5. Department of Biology; Boston University; Boston Massachusetts

6. Department of Genetics, School of Basic Medicine, Tongji Medical College; Huazhong University of Science and Technology; Wuhan China

Funder

National Program for Support of Top-Notch Young Professionals

National Natural Science Foundation of China

Academic Frontier Youth Team of HUST

Publisher

Wiley

Subject

Cell Biology,Ageing

Reference48 articles.

1. Sympathetic nervous system modulates the ocular hypotensive action of MT2-melatonin receptors in normotensive rabbits;Alarma-Estrany;Journal of Pineal Research,2008

2. Alzheimer's disease;Ballard;Lancet,2011

3. MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease;Banzhaf-Strathmann;EMBO Journal,2014

4. Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer's disease;Brunner;European Journal of Histochemistry,2006

5. STAT3 Target genes relevant to human cancers;Carpenter;Cancers (Basel),2014

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