Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape

Author:

Chen Zhaoyi12,Chang Wing Y.1,Etheridge Alton3,Strickfaden Hilmar4,Jin Zhigang4,Palidwor Gareth15,Cho Ji-Hoon3,Wang Kai3,Kwon Sarah Y.16,Doré Carole1,Raymond Angela1,Hotta Akitsu7,Ellis James89,Kandel Rita A.10,Dilworth F. Jeffrey1211,Perkins Theodore J.1511,Hendzel Michael J.4,Galas David J.3,Stanford William L.1261211ORCID

Affiliation:

1. The Sprott Centre for Stem Cell Research; Regenerative Medicine Program; Ottawa Hospital Research Institute; Ottawa Ontario Canada K1H 8L6

2. Department of Cellular and Molecular Medicine; University of Ottawa; Ottawa Ontario Canada

3. Pacific Northwest Diabetes Research Institute; 720 Broadway Seattle WA 98103 USA

4. Cross Cancer Institute and the Department of Experimental Oncology; Faculty of Medicine and Dentistry; University of Alberta; Edmonton Alberta Canada T6G 1Z2

5. Ottawa Bioinformatics Core Facility; The Sprott Centre for Stem Cell Research; Ottawa Hospital Research Institute; Ottawa Ontario Canada K1H 8L6

6. Department of Chemical Engineering; University of Toronto; Toronto Ontario Canada

7. Center for iPS Cell Research and Application (CiRA); Kyoto University; Kyoto Japan

8. Program in Developmental and Stem Cell Biology; The Hospital for Sick Children; Toronto Ontario Canada

9. Department of Molecular Genetics; University of Toronto; Toronto Ontario Canada

10. Pathology and Experimental Medicine; Mount Sinai Hospital; Toronto Ontario Canada

11. Ottawa Institute of Systems Biology; Ottawa Ontario Canada

12. Department of Biochemistry, Microbiology and Immunology; University of Ottawa; Ottawa Ontario Canada

Funder

Canadian Institutes of Health Research

Progeria Research Foundation

Heart & Stoke Foundation of Canada

Ministry of Research and Innovation

Luxembourg-ISB program

Canadian Heart & Stroke Postdoctoral Fellowship

Canada Research Chairs

Publisher

Wiley

Subject

Cell Biology,Aging

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